Manassero was just 20 years and 37 days old when he won a four-hole play off at Wentworth last month, and will be 21 days older if the year's second major championship concludes on schedule on Sunday.
John McDermott was 19 years old when he won in 1911, while Rory McIlroy was 22 when he triumphed by eight shots at Congressional two years ago.
The Italian has made the cut in his last two US Open appearances and believes this year's venue of Merion could suit his game.
"Some holes are really long, others are just wedges in so there is a real mix of holes and that's what makes this a really nice course," Manassero said. "You have to be sharp off the tee and with your wedges.
"I think it could suit me but basically it just suits whoever hits the ball well this week. Being this soft it is not going to be about bounce, it is just going to be about hitting good shots.
"The ball will stop and then it's about putting and chipping. The US Open is always a real challenge and it will be again this year.
"Winning the BMW PGA has given me a big lift. I wasn't playing that well but it was such a special week and ended a great week. It was the flagship event (on the European Tour) so Wentworth always has meant something special and to me, winning our main event meant a lot.
"It's great to win an event with such a strong field and this year with all the Ryder Cup players (bar the injured Peter Hanson), the event got what it deserved. It was a great title to win ahead of coming here."