Chang and Hsu fired matching one-under-par 70s to lead with their two-day total of four-under-par 138 at the Kuala Lumpur Golf and Country Club's East course in the RM180,000 (approximately US$60,000) Asian Development Tour tournament, which is the penultimate leg for the 2012 season.
Malaysia's challenge was carried by R. Nachimuthu, who fired a 72 to trail in joint third place on 140 alongside Scotsman James Byrne and Canadian Lindsay Renolds.
Byrne, a former Walker Cup star, fired a solid 69 to stay in contention while Renolds carded a second successive 70 to keep alive his hopes for a maiden victory on the ADT, which is the secondary circuit run by the Asian Tour.
Malaysian amateur Low Khai Jei continued to show his growing potential with a 70 for a 143 total to lie five shots back with two rounds to play. He is tied alongside Thailand's Tommy Mansuwan who also carded a 70 in his second round.
Play was suspended at 2.10pm for slightly over two hours due to an afternoon thunderstorm and after a brief resumption of play, the second round was stopped for the day following another weather disruption.
All the afternoon session players of the second round will resume play at 7.20am on Saturday with first round leader Brian Locke of the United States and Malaysian Ian Steele amongst those to finish their rounds.
The ADT has grown from five events since its inauguration in 2010 and has expanded to a record of 13 events this year. The ADT will also be afforded with Official World Golf Ranking status in 2013 which is a huge boost for the development of the game in Asia.