The 22-year-old picked up eight birdies in a bogey-free round to finish the 54-hole event in a tournament record 17 under.
That was well clear of closest challenger Caroline Masson of Germany, while France's Julie Greciet and England's Florentyna Parker tied for third on six under.
Spaniard Ciganda, who started the final round with a two-shot lead, told www.ladieseuropeantour.com: "I was just thinking about playing my game, having fun, and I liked the course from the beginning.
"I was playing good, I was confident and I think it's one of those weeks that everything goes right and I was lucky.
"I was making putts, hitting to the fairway, hitting lots of greens and then Javi, my caddie, did a great job.
"He was very good with the shots. I think it was everything."