Prandelli will be helped by the fact that Mario Balotelli could also make his Italy return against Denmark on Tuesday night.
The Manchester City striker has not played an international since his impressive Euro 2012 campaign, having missed the previous round of World Cup qualifiers after opting to have laser surgery on his eyes, and then sitting out Friday's 3-1 win over Armenia with a virus.
However, Balotelli has returned to light training over the weekend and could be ready to go tomorrow night.
"Balotelli responded well to tests (Saturday) and (Sunday)," team doctor Enrico Castellacci told reporters.
If Balotelli is able to play, it would be the 22-year-old's first match at the San Siro since he left Inter Milan for the Barclays Premier League in 2010.
However, the possible return of Balotelli has coincided with fresh selection problems for Cesare Prandelli, not least the likely absence of veteran goalkeeper Gianluigi Buffon.
The Juventus man has an adductor problem and sat out training over the weekend, possibly opening the door for Napoli's Morgan De Sanctis to start.
In defence, Christian Maggio could miss out after being given permission to return home at the weekend following the birth of his child.
He could be replaced by Ignazio Abate, while Giorgio Chiellini and Federico Balzaretti are pushing to start ahead of Leonardo Bonucci and Domenico Criscito.
All those decisions will give Prandelli plenty to ponder as he tries to inject some life into Italy's rather poor qualifying campaign so far.
Although they top Group B with seven points, two clear of Bulgaria, they have yet to really fire and were again unconvincing in coming from behind to beat Armenia on Friday night.
However, Prandelli was happier with his team than most of those watching.
"After the match we though we had played well, and then we read the papers and were presented with a different view," he said.
"But we needed a stimulus and we thought we had a good match. We prepared well. We risked the counterattack, but that's okay. It is better than being passive."
There are few recent meetings between the two sides to study, but those that were played offer little encouragement to Italy, with Denmark prevailing 3-2 in a Euro 2000 qualifier in 1999 before a goalless draw between the sides at Euro 2004.
If Italy have stuttered, so have Denmark, with two draws in two matches.
They collected their second point of the campaign in coming from behind to draw 1-1 at 10-man Bulgaria on Friday night.
Nicklas Bendtner, who has struggled to make an impact at Juventus this season, got the goal.
Denmark sit second last with just two points, but Prandelli was careful to give them plenty of respect.
"Historically, they are an opponent who have always created problems for us," Prandelli said. "They are not out of it. This group is very tight."