Lampard has a slight calf muscle tear while his Chelsea team-mate Bertrand has been suffering with illness, but Hodgson hopes one or both of them could be fit to face Poland next Tuesday.
Hodgson said: "Lampard had a scan earlier on in the week. He tried to train away from the team on Wednesday and still felt a slight problem with his calf muscle and it was re-scanned.
"They found a few fibres where there has been a slight tear. It is not a major problem but was decided the best thing is for him to go back to his club to get treatment on a daily basis and we will reassess on Sunday.
"When Ryan Bertrand fell ill, we were hoping it was one of those 24-hour things. It turned out to be a bit more serious than that.
"It is purely illness and we've sent him back to try and recover and we hope to see him on Sunday along with Frank."
Hodgson gave no indication today [Thursday] whether Ashley Cole would win his 99th cap against minnows San Marino, but he is looking to utilise his squad with the game in Warsaw already in his thoughts.
He said: "I could give you clues but I'm not going to because I haven't spoken to the players about the team.
"I've a good idea in my own mind of what I'm going to do but can't divulge that until I've spoken to the players.
"I don't know if it will be a question of experimentation tomorrow [Friday]. It might be a question of utilising the squad in a different way because we have a very important game in Poland on Tuesday.
"My thoughts this week have been based on how best to use the squad, knowing whatever team I choose at Wembley is likely to be able to win that game. How many players do I spare or keep fitter and fresher for Tuesday? That is the decision."
Hodgson has praised the England fans for making tomorrow [Friday] night's game a 90,000 sell-out despite the standard of opposition on view.
He said: "It is magnificent. It shows what fantastic support there is for football and national team football in the country and how lucky we are really to have an arena which takes 90,000 people who want to come and watch us play.
"We are very happy with it, concerned not to let them down and to do a good job."