Manchester City playmaker Nasri has completed a three-match ban imposed by the French Football Federation for his conduct at the European Championship in Poland and Ukraine but was not selected today [Thursday] by Les Bleus boss Didier Deschamps.
"I didn't think it was the right time to call him back," Deschamps said. "I prefer to wait a while.
"But before his minor injury he put together a very good start to the season. He has scored and contributed a few assists.
"He is available for selection but, again, I just felt it was not the right time."
Hatem Ben Arfa, another to have been disciplined over the summer, was also left out despite performing well for Newcastle recently with Deschamps instead including Toulouse midfielder Moussa Sissoko and Lassana Diarra, who recently moved to Anzhi Makhachkala from Real Madrid.
Diarra's inclusion for the first time since August 2010 is a surprise, but Deschamps admitted: "If Diaby and Mavuba were available, maybe he wouldn't be here.
"But he has always been on stand-by and it is a logical choice."
Deschamps is eager to see Sissoko in action having been impressed with his progress in Ligue 1.
"He is a young player but has great potential," he added.
"I want to get a closer look and hopefully he will be encouraged to do even better in the future."
Midfielders Abou Diaby and Rio Mavuba are injured but Montpellier full-back Mapou Yanga-Mbiwa is included even though he is suspended for the clash with world and European champions Spain on October 16 at the Vicente Calderon in Madrid.
France meet Japan at the Stade de France four days earlier as they look to build on World Cup qualifying wins over Finland and Belarus which has seen them move top of Group I.
"I am certain we will play a team at the highest level, but that doesn't mean we'll go over there as victims, thinking we can't do anything," Deschamps said.
"We have to try and cause them problems with the way we use the ball."
Spain will be without injured veteran centre-half Carles Puyol and possibly his Barcelona team-mate Gerard Pique for the clash at the Vicente Calderon, but Deschamps knows the home side will still possess plenty of quality.
"Maybe they are missing some players, but they are still the best team in the world," he added.
"The facts are there. No other team has won the European Championship, the World Cup and the Euro again."
The France squad is: Lloris (Tottenham), Mandanda (Marseille), Landreau (Lille); Clichy (Manchester City), Evra (Manchester United), Jallet (Paris St Germain), Sakho (Paris St Germain), Rami (Valencia), Yanga-Mbiwa (Montpellier), Koscielny (Arsenal), Debuchy (Lille); Cabaye (Newcastle), Gonalons (Lyon), Matuidi (Paris St Germain), Valbuena (Marseille), Sissoko (Toulouse), Capoue (Toulouse), Diarra (Anzhi Makhachkala); Benzema (Real Madrid), Giroud (Arsenal), Gomis (Lyon), Menez (Paris St Germain), Ribery (Bayern Munich).