The Mexicans, coached by Jose Manuel De La Torre, have nine points so far, five more than their rivals on Tuesday and seven more than El Salvador who take on Guyana.
The Tri won 2-0 against Costa Rica on Friday in San Jose and will now look to take three points from the Ticos once again to secure their place in the next round of qualifying.
Despite having almost secured qualification, De La Torre has ruled out making sweeping changes, and will be calling on his full squad, including Manchester United's Javier Hernandez and Valencia's Andres Guardado.
Much like his club form, Hernandez has been off-colour with the national team and has gone 418 minutes without scoring.
He is not worried, though, saying: "They are only statistics. It does not matter who scores. What matters is that the team win."
He added: "I'm not in a good moment, it's true, but I'm giving my best in every game and that's what counts."
The only change will be the inclusion of Jesus Zabala in place of the injured Severo Meza.
Costa Rica coach Jose Luis Pinto does not have the same luck with regard to fitness, with Bryan Ruiz and Roy Miller out and Michael Umana suspended.
Elsewhere, the United States have a job on their hands following a 2-1 loss to Jamaica.
They have to defeat the Reggae Boyz in Columbus to avoid a nailbiting end to qualifying.
With three rounds played, the Jamaicans are top of Group A with seven points, three ahead of the USA and Guatemala, who visit Antigua and Barbuda in St Johns on Tuesday.
USA manager Jurgen Klinsmann is clear on his side's task, saying: "We have no option, we must win this match.
"We have to learn from the mistakes we made in Kingston and never commit them again".
The German is without Landon Donovan and Michael Bradley, and is set to call in Carlos Bocanegra and Michael Parkhurst.
In Group C, leaders Canada take on Panama, while Cuba will look to get off the mark against Honduras.