The Euro 2012 finalists began their Group B programme with a nervy 2-2 draw in Bulgaria last Friday.
Pablo Osvaldo had fired the Azzurri into a 2-1 lead in Sofia with his first international goals but Cesare Prandelli's side were pegged back.
They will expect better against neighbours Malta having won all four of their previous encounters against the archipelago nation by a combined score of 15-2.
Prandelli will be without influential midfielder Daniele de Rossi after the Roma man limped off in Sofia but should still be strong enough.
Antonio Nocerino of AC Milan is likely to come into the team to play alongside Andrea Pirlo and Claudio Marchisio.
Prandelli may also consider other changes as he bids to shake his side out of their lethargy.
He told reporters: "It's been said we'll make a lot of changes, but the most important thing is for us to play quality football.
"We are Italy, and we must characterise something more than a simple tactical model. We have to rediscover our identity for Tuesday."
In terms of tactics, Prandelli has been criticised for starting with a 3-5-2 formation in Sofia and may opt for the 4-3-1-2 system which he used later in the match.
Malta, 133 places below sixth-placed Italy in the world rankings, go into the game on the back of a 1-0 loss to Armenia.
They are coached by an Italian in Pietro Ghedin, a former Azzurri assistant boss.
The match is being played at Modena's Alberto Braglia stadium as a show of support following the earthquake in the region earlier this year.
The other game to be played in the group this week sees Bulgaria at home once again, this time to Armenia, who are the only side so far to have claimed a win.
Bulgaria will now be confident of making an impact in a group that also includes Czech Republic and Denmark after their encouraging showing against the Italians.
Stanislav Manolev and Georgi Milanov were the men on target last week but the Bulgarians had further chances to snatch a shock win.
Despite that, Armenia will be no pushovers.
The former Soviet state are ranked 53rd in the world, 36 places above Bulgaria.
Substitute Artur Sarkisov scored their 70th-minute winner in Malta.