The 22-year-old has missed out on the previous two qualifiers after suffering a hamstring injury in late September while playing for Barcelona.
He made his return last week in the Champions League, coming off the bench to play in the last 17 minutes against Viktoria Plzen and he is ready for more time on the pitch.
Sanchez told Triunfo after arriving in Santiago to prepare for Chile's match against Uruguay, he said: "I am here for the 90 minutes. I feel I have the capacity to play, since I am no longer feeling any discomfort,"
"I am thrilled to be back playing and training, which is what makes me happiest."
"We can break history, just as we did during the previous qualifying campaign and if we continue playing like we have been," he insisted.
Chile take on Uruguay in Montevideo's Estadio Centenario on Friday, before hosting Paraguay four days later in the CONMEBOL World Cup Qualifiers.