The Albiceleste will begin the countdown to next summer's World Cup on Friday against an Ecuador team which has also qualified for the tournament in Brazil.
And Sabella believes the fixture, along with next week's meeting with Bosnia, provides the perfect setting to play around with his team.
"Ecuador have a very dangerous team, they are physically exuberant with good movement down the wings," he said.
"But I do not know if the coach is going to field an experienced squad or not.
"There is a chance to put two different teams up for these games. The aim, besides winning, is to give minutes to some players who have played very little or not at all."
Sabella was already facing changes following news of an injury to star attraction Lionel Messi, who is sidelined until the new year with a hamstring tear.
And although Argentina are keen to be involved with the striker's recuperation, the coach is confident he will be given the best possible care at club side Barcelona.
"Messi is Barcelona's player and they are a great club," said Sabella.
"We have sent a doctor to join Messi as back up, but we trust in Barcelona's doctor."
Defender Hugo Campagnaro and midfielder Fernando Gago will also miss the friendlies through injury.
Friday's all-South American clash will take place in New York and Ecuador midfielder Cristian Noboa believes they would struggle to find better opposition to pit their wits against.
He said: "This match gives us the chance to practise all the good things we did during the qualifiers.
"If we want to beat Argentina we will need to keep hold of the ball and defend well."
Team-mate Jayro Campos agreed they can expect a tough test.
"It is always a challenge to play Argentina," he said.
"They are one of the top national squads. We all know their potential, with or without Messi."