Two-time world champions Uruguay travel to Amman for the play-off first leg after finishing fifth in the South American qualifying group and will be expected to overcome a nation placed 64 spots below them at 70th in FIFA's world rankings.
However, Lugano is taking nothing for granted and says Uruguay will show Jordan respect as they try to secure their place in Brazil next year.
The West Brom defender was quoted as telling a press conference by news agency Efe: "We know Jordan has tough and fast forwards. They are a very strong team physically and their fans really get behind them.
"(We) will face the match with huge responsibility and knowing the goal of playing the World Cup is closer and closer.
"Uruguay respect our opponents but we want to win. Uruguay must play in every World Cup, and even more so if it is being played in Brazil."
Uruguay finished fourth at the last World Cup and also lifted the Copa America in 2011 but they know they run the risk of missing out on next year's finals if they take Jordan lightly.
Coach Oscar Tabarez warned his players: "It will be very difficult, especially the first leg.
"This is the last stage. We have the possibility to achieve our goal and we are looking forward to clinching it.
"We always think our opponents will do their best and if Jordan do their best, I'm sure it'll be a difficult match."
Uruguay are no strangers to the World Cup play-offs as this is the fourth successive time they been involved.
In contrast, Jordan are venturing into unknown territory as they look to reach a World Cup finals for the first time.
The Middle East nation have their work cut out to overcome a Uruguay side boasting the likes of Luis Suarez, Edinson Cavani and Diego Forlan, but coach Hossam Hassan insists his team should not be written off.
"We've come this far and we're optimistic we can make the Jordanian people's dreams come true and get to the World Cup," he said.
"We have done the first part of our job against Uzbekistan in the Asian play-offs and now we are looking to prepare well for Uruguay.
"The task is difficult but not impossible.
"We do not fear Uruguay but respect their history. All the teams who want to play in the World Cup must play against tough rivals."
The second leg will be played in Montevideo on November 20.