The build-up to the Cardiff City clash has focused on whether the world's most expensive player will be fit enough to play any part for the hosts after undergoing a scan on a groin injury on Monday.
The 24-year-old Real Madrid star went on to take a full part in Wales' final training session ahead of the Group A fixture, with a final decision on his fitness to be taken prior to kick-off.
Chelsea defender Ivanovic, is well aware of the quality Bale possesses having faced him on several occasions in the Premier League, but he believes Serbia have enough ability of their own to handle Wales, whether they can call on the former Tottenham man or not.
Ivanovic said: "Bale is one of the best players in the world, everyone knows that, but it is not just him. There are other great players in the Wales squad and they have played really well in some games.
"Bale is one of their main players but we do not know whether he will play or how long he will play, but we have to be ready to face a side with him or without him, and we are."
"It's difficult to stop him, he is a player who is always hard to mark. But for us it is important to play as a team as one individual cannot make that much of a difference over a game."
But Ivanovic does expect Bale to take the field at some stage in the Welsh capital.
"I expect him to play some part," he said. "It has been a very interesting period for him, he is an exciting player and he will be motivated to be back on the football field but we are ready for that.
"Facing him is one of the biggest challenges for any player, but at the same time it is one of the biggest motivations.
"It is a pleasure to face the best players."
Ivanovic also insisted the 6-1 win which Serbia - who currently sit third in Group A but, like Wales, have no hope of reaching the World Cup finals - enjoyed over the Dragons in Novi Sad last year will have little impact this time round.
He said: "In football it is always difficult and they will be motivated looking back at the 6-1 defeat the last time we played. We know that.
"They are at home, it has been a long time since the last game and it will be tough, but we are well-prepared."