Lampard is expected to join the likes of Sir Bobby Charlton, David Beckham and Peter Shilton in the 100-cap club on Tuesday night when England play Ukraine in Kiev.
The 35-year-old, who won his 99th cap against Moldova last Friday, has enjoyed 14 adventurous years within the England set-up, scoring 29 times and captaining the Three Lions on five occasions.
But despite all of the stunning right-foot drives, the clinical penalties and masterful assists, Lampard could not look back on his international career today without mentioning the nagging sense of disappointment that has been prevalent in every England player since the team last mounted a real challenge for a trophy in 1990.
Lampard has tasted three quarter-final defeats and one World Cup second round exit in South Africa, and unless England pull off a series of shocks in Brazil next summer- providing they qualify - his international career will have ended without success at a major tournament.
"There have been quite a few high points, but it's typical of all our England careers over the last 50 years that none of us have actually gone out and won anything, so there is a frustration about that," the Chelsea midfielder said.
Lampard made his debut way back in 1999 at the Stadium of Light where an England team containing the likes of Paul Ince, Alan Shearer and Tony Adams beat Belgium 2-1.
Having been brought up listening to stories from his father Frank Snr, who won two caps, about West Ham and England greats like Bobby Moore, Lampard is well aware of how big a landmark reaching 100 caps is.
"It will mean a huge deal to me and to my family," Lampard said.
"I was lucky enough to grow up in a football family. It was my life from a very young age.
"My dad had a huge amount of respect for Bobby Moore so I realised from a very young age how much of an honour it was to play for your country. It's a huge thing for me.
"I would like to think I carry some of those traits (that Moore had)."
Lampard listed scoring his first tournament goal at Euro 2004 as one of his highlights, and the low points include that infamous strike against Germany in Bloemfontein which was never given.
A wide smile spread across Lampard's face when he spoke of the idea of joining such an illustrious club, but 12 months ago he must have doubted whether this day would come.
Then, despite showing some of the best form of his career, Lampard's future was uncertain for the first time since he moved to Stamford Bridge in 2001. With Chelsea determined to lower the average age of their squad, they refused to offer him a new deal. After snubbing a move to the Los Angeles Galaxy, Chelsea finally came to their senses and offered their vice-captain a one-year extension, which he gladly signed.
Lampard finished last season with 23 goals and he has maintained his form for his club following the return of Jose Mourinho.
Still in good shape for a man in his mid 30s, Lampard says he has no intention of hanging up his boots any time soon, although he does admit a career in coaching will probably follow his retirement.
"I want to play for a good few more years," he said.
"I will try and concentrate on that and then I will see what comes open. I certainly wouldn't rule anything out after that. "I am a football person so I would like to be involved in the game."
Lampard's Chelsea team-mate Ashley Cole was afforded the honour of captaining England shortly after he reached 100 caps, but the midfielder does not want to skipper the side in Kiev.
"There has been no discussion about that and personally, I don't think it's really needed," Lampard said.
"Stevie is a great captain so I wouldn't want to do that. You don't want to chop and change too much."