If, as expected, Lampard is selected to face Ukraine in Tuesday's World Cup qualifier in Kiev, he will follow team-mates Steven Gerrard and Ashley Cole to three figures.
And while his first goal at a major tournament finals, in Euro 2004, marks one of his highlights with the Three Lions, his disallowed strike against Germany in the 2010 World Cup will count in the opposite column.
Lampard's shot in Bloemfontein beat goalkeeper Manuel Neuer all ends up, crashed off the crossbar and bounced at least two feet behind the goal line, but spun back into play and the goal was not awarded by the match officials.
The incident was one of the major inspirations behind the introduction of goal-line technology, though, giving Lampard an important if unwitting role in shaping football's future.
"Bloemfontein was a particular moment, thank God it brought something good in end with the technology coming in," he said.
"But that's one of (the lows), that and missing a penalty and getting knocked out (of the 2006 World Cup) in Germany against Portugal. There's nothing worse than flying home when you've been knocked out of a tournament."
Asked for his favourite of the goals that did stand, he said: "It would be the header in Euro 2004 against France, my first major tournament goal.
"We ended up losing the game but personally, to do something like that on a major stage, I was overwhelmed. Scoring in that atmosphere was fantastic.
"The personal highlights are qualifying for championships, and ideally getting to 100 caps will be a highlight in itself. I've enjoyed every minute of travelling and playing tournaments with the country.
"It's like all our careers, though, in some respects - in the last near-on 50 years we've not gone and won anything."
Lampard will await manager Roy Hodgson's selection for Tuesday's match, though it seems highly unlikely the 35-year-old would be overlooked.
"Roy hasn't said, so I'll just wait and try to prepare like always," he added. "I'll be proud if I start or get on at any stage.
"But the main thing is to get a result, it wouldn't be enjoyable for me to get to 100 and then not get the result so we've got to do it the right way.
"I never dreamt of getting near 100 caps so it's a huge honour for me and I won't take it lightly."
Previous centurions have been handed the captain's armband to honour the occasion - albeit after some confusion in the case of Cole, following Hodgson's bungled announcement - but Lampard said: "I don't think that's needed.
"We've got a great captain so we don't need to chop and change it too much. It's an important game and we've all got to be captains on the pitch."