The matches, which will follow a two-legged format will take place from Monday July 2 to Monday July 9.
There are some eye-catching clashes with smooth-flowing Albirex Niigata taking on Tampines Rovers while Home United will meet SAFFC.
Loyola Meralco Sparks from Philippines and KBZ FC, the only foreign sides still in the competition will face-off against each other while Hougang United will play Gombak United in the fourth quarter-final.
RHB Singapore Cup Quarterfinals Schedule
Monday, July 2: Albirex Niigata vs Tampines Rovers at Jurong East Stadium
Tuesday, July 3: Gombak United vs Hougang United at Jurong West Stadium
Wednesday, July 4: Home United vs SAFFC at Bishan Stadium
Thursday, July 5: Loyola Meralco Sparks vs Kanbawza FC at Jalan Besar Stadium
Friday, July 6: Tampines Rovers vs Albirex Niigata at Clementi Stadium
Saturday July 7: Hougang United vs Gombak United at Hougang Stadium
Sunday, July 8: KBZ FC vs Loyola Meralco Sparks at Jalan Besar Stadium
Monday, July 9: SAFFC vs Home United at Choa Chu Kang Stadium
*All matches will kick-off at 7.45 pm local time.