DPMM took the lead in the 25th minute after Walid Lounis bundled the ball into his own net, before the Bruneian outfit doubled their advantage through Shahrazen Said 11 minutes later.
Ghanaian striker Basiru Osman wrapped things up in five minutes into the second half when he added a third, ensuring that DPMM - a leading light in the S.League before their FIFA-induced ban in 2009 - moved top of the table, two points head of Home United.
"My dream is to play like we did in 2009," DPMM coach Vjeran Simunic said after the match.
"I am happy that we now have 14 points, the same as we did at the same stage three years ago. On top of that, this season's opponents are a little better," he added.
Elsewhere on Friday, Hougang United backed up on last week's impressive 1-1 draw with defending champions Tampines Rovers with a 3-1 victory over Woodlands Wellington.
The Cheetahs took the lead through Canadian livewire Jordan Webb in the 29th minute, before he doubled his tally four minutes after the break from the spot.
Croatian centre-back Stanislav Vidakovic made sure of the three points in the 56th minute, before Goh Swee Swee got a late consolation for the Rams.
"I must congratulate my players as they took this game very seriously," Hougang coach Nenad Bacina declared.
"We controlled the game all the way and I think we deserved all three points."
On Thursday, Tampines got their title defence back on track with a 2-0 win over Home United, while Tanjong Pagar United recorded their first three points of the season with a 1-0 triumph over Geylang United.
On Sunday, Harimau Muda look to continue their unbeaten start to the season against SAFFC, while Courts Young Lions will look to pick up their first points of the season against high-flying Balestier Khalsa.
Friday's S.League Results
Gombak United 0-3 DPMM FC
Woodlands Wellington 1-3 Gombak United
Thursday's S.League Results
Sunday's S.League Fixtures
SAFFC vs Harimau Muda
Courts Young Lions vs Balestier Khalsa