The 51-year-old has kept his counsel amid rumours he is set to leave the San Paolo bench at the end of his contract in pursuit of a role elsewhere.
The Tuscan has been strongly linked with Andrea Stramaccioni's job at Inter Milan with hosts Roma a more likely destination given Aurelio Andreazzoli's interim status as head coach.
And Mazzarri admitted he will leave Naples for pastures new if no new contract is signed in the coming days.
He told La Repubblica: "I've said that I will make my mind up at the end of the season, and there is still one game remaining.
"I will explain everything after the game with Roma, I don't know whether it will be immediately or in a few days, but you will know everything.
"Timing is everything in these situations. If I tell you that I need more time, then I must have my reasons. I'm asking for some respect.
"I'm out of contract and it is my right. The club management, in their own way, have the right to make their decision. And, unless we can reach an agreement, there will be a parting of the ways."
Defender Hugo Campagnaro misses out at the Stadio Olimpico while striker Lorenzo Insigne serves a one-match ban.
Whatever happens in the capital city, Mazzarri is delighted to have led the Azzurri to second place, their highest league finish since 1990.
"With another three points we will consolidate this new record in the history of Napoli," he said.
"Even if we were to lose in Rome, we would have picked up 28 more points than the teams that started this cycle four years ago.
"The fact we are fighting for the title is already a small victory. If we keep working in this way, we will have success.
"If we had won the two head-to-head meetings with Juventus then we might have won the championship but let me be clear, the Bianconeri have deserved it."
Roma striker Francesco Totti, meanwhile, is suspended with goalkeeper Maarten Stekelenburg unlikely to feature due to injury.
Giallorossi coach Andreazzoli is similarly tired of hearing rumours about his own future, insisting he has done enough to keep his job at the Olimpico after both stabilising Roma in the league and booking a berth in next week's Coppa Italia final.
He told asroma.it: "What would I do if I received an offer from another club? I'm good at my job and I feel I could do well here or elsewhere.
"I'm in control of my own destiny and the decision is mine."