Mirko Vucinic put Juventus in front in the second minute with Andrea Pirlo and Claudio Marchisio adding further goals within the first 30 minutes.
Thomas Manfredini was then shown a red card for Atalanta, who were fortunate to avoid any further damage as Juve continued to attack but could not add to their first-half salvo.
Bologna pulled away from the relegation zone with an unexpected 3-2 win that dented high-flying Napoli's title hopes.
Despite going behind to Manolo Gabbiadini in the 10th minute, Napoli turned the game through Alessandro Gamberini and Edinson Cavani.
But two goals in three minutes from Panagiotis Kone and Daniele Portanova earned Stefano Pioli's side a shock win to leave Napoli eight points shy of Juve.
AC Milan claimed a fourth consecutive victory by downing struggling Pescara 4-1.
Antonio Nocerino found the back of the net inside 35 seconds and Elvis Abbruscato undid Pescara's promising defensive work with an own-goal.
Cristian Terlizzi briefly dragged the visitors back into the game but Jonathas headed into his own net in the final stages, leaving Italy striker Stefan El Shaarawy to rubberstamp the victory.
Earlier in the day, Fiorentina moved into the top five with a comfortable 4-1 win over local rivals Siena in a one-sided Tuscan derby.
Luca Toni and a David Pizarro penalty put Fiorentina ahead within 20 minutes, with Alberto Aquilani wrapping up victory on the stroke of half-time.
Reginaldo pulled a goal back for Siena, but Toni's second restored Fiorentina's three-goal advantage and took them to within two points of second-placed Inter Milan.
Siena ended the game with 10 men as Massimo Paci was shown a second yellow card, but Aquilani missed the resulting penalty.
A late goal from Sergio Pellissier earned Chievo a 1-0 victory that denied Roma the chance to catch Fiorentina.
A draw seemed the most likely outcome at the Stadio Marc'Antonio Bentegodi, but Pellissier struck three minutes from time to ensure the points would stay in Verona.
Parma survived an early scare before three second-half goals ensured they would down Cagliari 4-1.
Roberto Donadoni's side recovered from going behind to Marco Sau's 20th-minute opener as Ishak Belfodil equalised one minute later and Jonathan Biabiany, a Jaime Valdes penalty and Belfodil's second goal late on kept Parma inside the top half.
Catania registered back-to-back league wins for the first time this season by coming from behind to beat Sampdoria 3-1.
Enzo Maresca converted an early penalty before Catania substitute Mario Paglialunga levelled after the break.
Gonzalo Bergessio boosted Rolando Maran's men into the lead with a close-range header and Catania made the points safe through Lucas Castro's effort on the stroke of full-time.
Elsewhere, Andreas Granqvist earned Genoa a 1-1 draw against fellow strugglers Torino after Rolando Bianchi headed the opener.
Sunday's Serie A Results
Saturday's Serie A Results