The victory was wrapped up within the opening 20 minutes with goals from Andrea Pirlo, Arturo Vidal and Alessandro Matri putting the Bianconeri in the driving seat.
Pablo Osvaldo pulled a goal back from the penalty spot for the Giallorossi but Zdenek Zeman's men were unable to find a way back into the game and Sebastian Giovinco added a late fourth to leave Roma eight points behind the Bianconeri in the Serie A table.
Parma earlier held AC Milan to a 1-1 draw at the Stadio Tardini, halting the Rossoneri in their tracks after they looked to have recovered from a poor start to the season.
Stephan El Shaarawy, who was Milan's hero in their midweek 2-0 win over Cagliari, put Massimiliano Allegri's side in front early in the second half but Daniele Galloppa equalised in the 66th minute to earn Roberto Donadoni's side a draw, which leaves them just a point behind their visitors.
Saturday's Serie A Results
Juventus 4-1 Roma
Parma 1-1 AC Milan