The Nerazzurri's 1-0 loss at relegation-threatened Lecce on Sunday snapped the club's seven-match winning streak in Serie A.
The result dropped Inter to fifth place, nine points behind league leaders Juventus.
And, while there are many games to be played, Inter coach Claudio Ranieri knows the setback at Lecce has provided a big blow to their hopes of winning the title.
"We have to look ahead," Ranieri told www.inter.it.
"We are three points behind Udinese, who are third in the standings.
"To qualify for the Champions League is our aim."
Palermo have yet to win on the road this season.
AC Milan coach Massimiliano Allegri could hand new signing Maxi Lopez his debut at Lazio on Wednesday night.
The Argentina striker joined the Rossoneri on loan from Catania last week but did not feature in Milan's 3-0 triumph over Cagliari on Sunday.
Udinese have collected 28 points of a possible 30 at the Friuli stadium, where they take on Lecce.
The win over Inter was Lecce's first at the Via del Mare stadium and lifted Serse Cosmi's men to 18th place, just three points adrift of safety.
Roma's four-match winning run in Serie A came to an end on Sunday when they were held to a 1-1 draw by Bologna.
The Giallorossi, who are sixth, lock horns with Cagliari in Sardinia next.
Napoli take on Cesena at the San Paolo stadium looking to leave behind a disappointing month of January.
The Naples outfit have mustered one win in its last four league games to drop to seventh place.
Meanwhile, Novara coach Attilio Tesser will be under pressure to take a win in Thursday's game against Chievo.
Last weekend's 2-0 setback at Palermo was Novara's fourth straight loss and left them at the foot of the standings, seven points away from safety.
On Tuesday, Juventus's game at Parma was called off due to severe snow, while the same weather conditions also caused Wednesday's matches between Atalanta and Genoa, Bologna and Fiorentina, and Siena and Catania to be postponed.
Tuesday's Serie A Fixtures
Wednesday's Serie A Fixtures
Atalanta P-P Genoa
Bologna P-P Fiorentina
Siena P-P Catania