Inter Milan are hovering above the drop zone with eight points and a better goal difference than Lecce after a dismal start to the season.
Samuel still believes that the Nerazzurri still has what it takes to climb back to the top of the table, given the close nature of competition in the Serie A this season.
The Argentine called for the team to take each game one at a time and focus on getting a run of good results.
"We have to focus on each game because we know that if we play well we can beat any team," the defender told Inter Channel.
"On Saturday we will be playing Cagliari and we will do our best to win the game.
"We must not forget that with two or three consecutive wins we can be right back up there.
"We will not give up on the league as anything can happen."
Napoli, who are sixth in the league, have 14 points, only two more than Parma, who are 15th.
Inter Milan have eight points and a game in hand, which means that they may break into top half of the league with a string of wins.