Saturday's 2-0 home reverse to Lecce was Bologna's second loss in succession to leave them bottom of the standings, a situation in stark contrast to Wednesday night's hosts Juventus, who kicked off the campaign with two straight wins.
A third defeat on the spin looks a real prospect for Bisoli's men, but the coach, who only took charge in May, has demanded time to rebuild his squad before the knives come out in earnest.
"We're playing against a big side, in a wonderful stadium. We need to gradually continue our work, with determination, and try to improve the situation," said Bisoli.
"I've been through the game against Lecce six times. Nothing's gone in our favour, we've been through the mill.
"The public's booing is understandable, but we've been panned by the critics after only 180 minutes. Patience is required.
"This hasn't been my team up until now, it hasn't been a Bisoli side.
"Now results are what's needed, the only useful remedy."
Juve, meanwhile, head into the match buoyed by a perfect start to the campaign which has brought two wins from two, five goals for and just one against.
The expectation is Juve will ease to victory at their new state-of-the-art 41,000-seater stadium, but coach Antonio Conte is preaching caution.
"Nothing is easy," he said. "We are meeting a team that has zero points in the standings but there's nothing to take for granted and we have tried to prepare the game well, despite the short time available."