AC Milan face a tough game at Napoli, who followed up their 3-1 win at Cesena with a 1-1 draw at Manchester City last night.
Antonio Conte has got off to a good start as coach of Juventus, the club he once played for.
He is likely to have strange emotions this weekend when he leads the Turin giants in Tuscany against Siena, the side he led to promotion last season.
Juve, who are not competing in Europe, thumped Parma 4-1 last weekend.
Lazio, who got goals from summer signings Djibril Cisse and Miroslav Klose in their season-opener against Milan, host Genoa.
Palermo, having come from behind twice in their victory over Inter, play at Atalanta on Sunday.
Fiorentina had just three wins on the road last season so they will be hoping for an improvement starting with their first away game this weekend at Udinese.
Parma will try and bounce back from their heavy defeat at Juventus when they host Chievo on Sunday.
Bologna will be bolstered by the return of Jose Angel Crespo, Daniele Vantaggiato and Gaston Ramirez for Sunday's match against Lecce.
The trio missed last weekend's 2-0 defeat at Fiorentina through suspension.
Catania coach Vincenzo Montella expects a vast improvement from his players in Sunday's game against Cesena.
The Sicilian outfit was held to a goalless draw by Siena in their first game.
Inter Milan and Roma both picked up their first point of the season in a combative draw at the San Siro which leaves the future of the respective coaches far from certain.
As in the midweek defeat to Trabzonspor, Inter coach Gian Piero Gasperini heard boos echoing around the stadium and was left still waiting for his first win in charge after four attempts.
Roma boss Luis Enrique, on the other hand, will know that what would normally be regarded as a good point in Milan does little to help his own cause.
There was also a worrying injury for Roma goalkeeper Maarten Stekelenburg, who was taken to hospital after receiving a boot to the head from Inter defender Lucio and was reported to have briefly lost consciousness.
As for the result, after such a tense encounter with few clearcut chances, neither coach can have too many complaints that their first win of the season will have to wait until at least the middle of next week.
Cagliari edged a tight encounter with Novara at the Stadio Sant Elia with goals from Thiago Ribeiro and Joaquin Larrivey taking the Sardinians to the top of Serie A, at least for a night.
Thiago Ribeiro's first goal in Serie A opened the scoring in the 38th minute and Larrivey added the second four minutes from time.
A consolation effort from Takayuki Morimoto just before the final whistle was not enough to deny Cagliari their second 2-1 win in succession as they rose to the top of the pile ahead of the rest of the weekend's matches in Serie A.