Juventus are 14 points clear at the head of the table having lost just once in the league all season, with Roma separating them from Rafael Benitez's Napoli.
A 3-0 win in Turin earlier in the campaign will give Juventus plenty of confidence as they travel to Naples on Sunday but former Real Madrid attacker Callejon is keen for the hosts to come out on top.
"Juventus is an important game for us and for all of Naples," he said.
" We all know that it is particularly special game for our fans. We would like to do well because we have the goal of second place and we will try until the end. There are still many points to play for and we will fight in every game.
Callejon moved to Stadio San Paolo from Madrid last summer and has scored 13 goals in all competitions so far as Benitez has relied on the former Spain Under-21 international and Gonzalo Higuain to fire Napoli back into the Champions League.
With a six-point deficit to Roma, Benitez will still be looking for a top-two finish and an Italian Cup success at the end of his first season, with Callejon happy with his own maiden campaign in Italy.
"I'm happy because I have the confidence of the manager and players," he added.
"I try to give everything and this is the path on which to continue. Benitez is important for this project and in the coming years - this is our first season with a new formation and a different technician."
Juventus, who have won 26 of their 30 league games so far, will be without the suspended Carlos Tevez for the trip to Naples as the 18-goal striker serves a one-match ban.
His absence could be a costly one, but Juve coach Antonio Conte remains at ease about who will replace him.
"Carlos isn't available but someone will take his place," he said.
"We are feeling relaxed, especially after a win over an excellent Parma side."
Tevez scored both goals in Wednesday night's 2-1 home win over Parma but, with Fabio Quagliarella, Dani Osvaldo and Sebastian Giovinco all fit and available, Conte will be hoping whoever he picks can fill in the void.