Both sides are in fine form in Serie A but league leaders Juventus perhaps boast the most impressive statistic this season having won all 14 league games at their three-year old base in north Turin.
Undefeated since November 2 - a date which saw Juve win 1-0 at the Stadio Ennio Tardini - and the victors on all five of their away days in 2014 are Parma, who are chasing fifth place and a return to European competition.
Speaking ahead of his team's departure for Turin, Donadoni told reporters: "Juventus have been ruling the roost there for three years now and we know we have a difficult task on our hands.
"It will be nice to face them in a high-quality stadium where we'll need to produce a performance of the highest level and give 110 per cent - that's the only way we'll be able to think about taking points from the encounter.
"The stadium makes the difference for them, but we've got plenty of motivation, enthusiasm and desire to do well in such a prestigious setting."
Midfielders Jose Mauri and Walter Gargano and striker Nicola Pozzi are unavailable through injury while Juve boss Antonio Conte has concerns over defenders Angelo Ogbonna, Federico Peluso and Andrea Barzagli.
The season is over for midfielder Simone Pepe while strikers Carlos Tevez and Fernando Llorente both risk a one-match ban should they pick up bookings on Wednesday.
Bianconeri full-back Simone Padoin has warned Parma that the reigning champions are not willing to let anyone "escape" Turin unharmed as they close in on a third straight Scudetto.
"It will be a very compelling game," he told juventus.com. "They've only picked up slightly fewer points than we have in 2014. They are in great physical and mental condition and will arrive eager to win the game.
"But they will meet a Juve side who do not want to let anyone escape.
"The unbeaten stand at our stadium must continue and hopefully our fans will back us like they always do - they really are our 12th man."