The Sardinian outfit have not won on the road in Serie A since February 17, a 2-0 triumph at Pescara.
With just three points - all from draws - collected away from Cagliari this season, Diego Lopez's men have had to rely on home comfort to remain clear of the drop zone.
Last weekend's 2-1 triumph over Genoa was Cagliari's fourth win of the campaign and lifted the islanders to 11th position, level on 18 points with Parma, who are 10th.
"We have to build on this result," Lopez said. "It would be a big boost in confidence to take a win away from home before the end of the year.
"We know we face a stern test at Parma but if we show the same hunger and determination as we did against Genoa, there's no reason why we cannot take home three points."
Parma will be no pushovers. They held Inter Milan to a 3-3 draw at the San Siro last time out to extend their unbeaten run to four games.
However, Parma coach Roberto Donadoni was not pleased with that result and felt his side threw away two points.
"To score three goals at the San Siro, have three or four more opportunities to score and not take home a win is disappointing," Donadoni said.
"It's true that we should have been more focused on defence and not given away three goals.
"We still have a lot of work to do to get to where we want to be."
Parma have lost just twice at home this season - against Serie A leaders Juventus and unbeaten Roma.
The hosts will be without midfielder Marco Parolo, who serves a one-match ban, while defender Djamel Mesbah is out injured.