The two clubs head into the game locked together on 36 points - four points above the relegation zone - and in the knowledge that victory could be enough to ensure survival depending on results elsewhere.
Granada have given themselves hope by going on a run of four games without defeat including last Monday's hard-fought 2-2 draw at Real Sociedad, and Aranda has called on his team-mates to maintain their momentum.
Aranda said: "It is a difficult game against a direct rival and we need to stay calm and get the win.
"We are going into a tough game where the stakes could be survival. But it is most important that we think only of ourselves and win the game before we see what happens elsewhere."
Osasuna also have renewed hope heading into the game after they ended a five-game winless streak with a vital 1-0 win over Getafe last Saturday.
Coach Jose Luis Mendilibar said: "Winning this game could be decisive so both teams will be fighting to the death to win. We feel better after last week but now we must go out and do it again.
"Granada are a strong team and they can cause some damage. They are aggressive and they always reach forward. It might be the case that a draw is a good result for us, but it only depends on other results."