Atletico, who are now six points behind Los Blancos, travel to Sevilla on Sunday looking to keep pace with their rivals, who do have a UEFA Champions League semi-final tie against Borussia Dortmund to worry about.
Both sides also meet in the Copa del Rey final on May 17 and Rojiblancos winger Juanfran wants to finish the season with a flourish.
"For us it is a very exciting final course," he said. "We have some big games in which everything will be decided and we will see if our season has been good, very good or great.
"We want to finish second and win the cup final, but first we have a match against Sevilla.
"Encounters at the Sanchez Pizjuan are always very hard."
Fourth place Real Sociedad travel to Osasuna on Sunday looking to tighten their grip on the final Champions League qualifying spot, while Getafe take on Espanyol and Athletic Bilbao travel to Deportivo la Coruna.
Two teams in the drop zone play on Monday night as Celta Vigo host Zaragoza.
On Saturday, Barcelona continued their march to the title with a gritty 1-0 triumph over Levante, while a Mesut Ozil double helped Real Madrid to a 3-1 home win against Real Betis.
Valencia remained in the hunt for a top-four finish after recording an impressive 5-1 victory over Malaga, while Granada and Real Valladolid played out a 1-1 draw.
Meanwhile on Friday, Real Mallorca moved up to third from bottom as they continue their fight against relegation from the La Liga with a 1-1 draw against Rayo Vallecano.
Sunday's La Liga Fixtures
Monday's La Liga Fixture
Celta Vigo vs Real Zaragoza
Saturday's La Liga Results
Friday's La Liga Results