Zenit and AC Milan were drawn along with Anderlecht and Malaga in Group C last week and while the Italian side appear to be favourites due to their status as traditional continental powerhouses, but Spalletti feels that his side will be able to give the Rossoneri a run for their money.
"Are Milan the favourites? I expect a balanced group, which makes things more complicated," Spalletti said on Sky Sport Italia.
"In the time I've worked in Russia we have made the most of our capabilities and managed to win some trophies.
"With the Champions League, we'll have to work even harder. This is why we signed Hulk and Alex Witsel, as they are important additions to the existing squad."
Zenit begin their Group C campaign with a visit to La Roselada to face Malaga on Tuesday September 19th.