The Portuguese coach spoke for the first time in many months in a press conference, preferring to let assistant Aitor Karanka handle it often in the past few months. He gave a wide-ranging speech that covered Guardiola's departure, his own ambitions of winning a league title in three major European leagues and Cristiano Ronaldo's quest to win the Ballon d'Or.
Mourinho will lead his side in the title clincher knowing that a win will make it mathematically impossible for Barcelona to catch up with them. They currently boast a seven-point lead over their Catalan rivals and have three games left.
He is happy to win his first La Liga title in the city of Bilbao, lauding it for its love of football and for being a tough opponent. He knows that it will not be easy to win against Marcelo Bielsa's side but he is confident that his team has what it takes to secure the crucial three points.
"I like to play in Bilbao. The stadium has a crowd that is passionate about football and that fervently supports its team. People who love football and the atmosphere of great games like to play there, and my team does. We've recently played in similar stadiums, like Camp Nou, the Calderon and the Reyno de Navarra.
"They are harsh on opponents. Athletic Bilbao play very well, but so do we.
"Other sides have faced Athletic when the latter have used few regular starters, but we won't have that luck. All their main players rested in the previous game and they consider tomorrow's [Wednesday's] clash to be important. Athletic have a solid squad and quality players."
"We will try to win in order to be champions, but they will do their best to defeat us and prevent us from winning the title at their stadium."
He was quizzed on whether he was happy to get the opportunity to win as manager in three European leagues and he admitted that it was a stated goal of his but he is keen to secure more championships in the near future.
"We haven't won yet, so the fact that I've won all three major European league championships is still hypothetical," he pointed out.
"We know we're close and that we'll achieve it soon, either tomorrow, on Saturday or later on.
"We are confident in ourselves and we'll experience great joy when we win the title.
"I don't think this will be my last La Liga title and I think we'll have a chance to celebrate other things in the future, but one of my personal goals indeed was to win the three major European league championships.
"I will be very happy if I manage to do so, and I'm sure I will."
He dismissed rumours that hinted that club legend and sporting director Zinedine Zidane could be on his way out. He stated that everyone was vested in the club's success and he has established a fruitful relationship with the coaching staff and especially his assistant coach. He even declared that should he leave the club in the future, Karanka would be more than welcome to join him in his next adventure.
Cristiano Ronaldo has had a superb season for Real and Mourinho is also confident that his compatriot will win the Ballon d'Or. But he pointed out that it's important for Real to win the league if the winger is to have any chance to win the world's top prize.
"Cristiano Ronaldo's main objective is to win the league title and his second objective is to win the Ballon d'Or.
"The latter isn't won by the top scorer, but by the player who wins a great collective title. You cannot win the Ballon d'Or if you don't win the league title or the Champions League.
"I don't think Bayern Munchen or Chelsea have anyone better, so I think he'll win the Ballon d'Or if he wins the league title."
And finally, the press were especially eager to hear about Mourinho's reaction to the departure of Pep Guardiola. He was nonchalant in his comments and hoped that his rival would enjoy the break from football.
With regards to Tito Vilanova, Guardiola's replacement, the Real coach abruptly remarked that he would be getting no favours from the Madrid side as he would be in charge of his opponents.
"Guardiola has decided to leave Barcelona. When we coaches are dismissed we are deserving of solidarity and praise.
"Guardiola's has been a personal decision and he knows what will make him happier.
"The important thing is that he's happy with his decision. I've been coaching for 12 years and I will miss football in June, when there will be no more games to play.
"I wish he enjoys his time because that's the most important thing in life.
"I believe Barcelona have capable executives and, if they believe Vilanova is the ideal replacement for Guardiola, we respect their decision.
"He will be our opponent in La Liga next season. We cannot wish him luck because they are our most immediate opponent."