Madrid currently hold a commanding five point La Liga advantage over the Catalans ahead of Barca's Sunday clash with Malaga.
"We know that in the Liga we are behind a rival that doesn't lose points and we cannot allow any more to slip away. If we don't want their advantage to grow at the top, we cannot lose more points," Guardiola was quoted as saying on the club's official website.
The Barcelona honcho is under no illusions of the task awaiting his charges against Manuel Pellegrini's men.
"The teams managed by Pellegrini always play well," Guardiola explained.
"Málaga is a very solid team, with a manager and footballers that have a lot of experience. Their left and right backs play very deep, their wingers know how to play and their strikers look for spaces. In general, they are quality players."
Guardiola also lamented the month of January as the "most difficult month of the year,"
"You come back from vacation, the climate ... the demand, in every sense, is very high. There isn't time to think about what happened two or three days ago, you just have to move forward to see where you end up."
"It's a month that wears you down because you're either in or out of the final of an important competition like the King's Cup."
The Barca tactician was also unwilling to delve into the comments made by Jose Mourinho regarding the Pepe saga after the Portuguese apologized for stamping on Lionel Messi's hand.
"I don't respond to what is said in press conferences held by my colleagues," he added.
Guardiola though was only too happy to discuss about the impending return of midfielder Pedro.
"It's great news. We're talking about a player that I have a lot of affection for, he gives the team a lot of things," he said.