Earlier this week, defending champions Barca were held to a 2-2 draw by an attacking Valencia outfit which caught the Catalan side out cold many times in the first-half.
The manner in which Los Che looked to match their opponents was a fresh breath of air compared to the approach most teams employ when playing against Barca - setting their stall out to defend.
And on Saturday, Guardiola will have to contend with another attacking outfit in the form of Atletico, who are fresh off the back of a 4-0 win over Sporting Gijon.
While Barca have had a good record against Saturday's opponents recently, Guardiola was keen to stress that Atletico were a very different outfit under new coach Gregorio Manzano, who took over the the Vicente Calderon in the summer.
"This season's Atletico play in a different way," Guardiola said at his pre-match press conference.
"The team have Manzano written all over them. They play very well and keep being very organised, just like they were under [former coach] Quique Flores, but they play more through the middle.
"They have scored many goals and conceded just one, while creating many chances.
"I did not expect them to be doing well and to have made such good signings."
Barcelona struggled at times against Valencia largely because the players were unfamiliar with a 3-4-3 system Guardiola employed, something the coach could look to change on Saturday.
"If I deploy three defenders, it is to attack better, to create more spaces, not to defend.
"I reviewed the game against Valencia today [Friday] and if our opponents do things well it's because they are good, not necessarily because we made mistakes."
Barcelona are currently fourth in La Liga on eight points, four behind surprise leaders Real Betis.