The Brazilian full-back should miss a week to 10 days of action after suffering a slight tear to the soleus muscle of his right leg.
That rules him out of the La Liga clash with Granada as well as the Champions League game at Ajax, with his participation against Athletic Bilbao on December 1 also in doubt.
"Tests carried out on Thursday morning have confirmed that Dani Alves has a slight tear of the right leg soleus muscle. He'll be out for between seven and 10 days," read a statement on Barcelona's official website.
"In principle, Alves will miss the games against Granada and Ajax."
While his injury is not a long-term concern, it does give Barcelona boss Gerardo Martino an added headache as the full-back joins fellow first-team players Victor Valdes, Jordi Alba, Gerard Pique, Cesc Fabregas and Lionel Messi on the sidelines.
The Catalan club also confirmed that Xavi is a slight doubt for Saturday's encounter with Granada.