By FOX Sports Staff
Van Nistelrooy, who scored an incredible 150 goals in five seasons at Old Trafford, described the impact of his fellow Dutchman in his debut season as "massive".
Van Persie's 26 league goals helped fire United to the league title this season and allowed him to win the Golden Boot award for the second year running - he was top scorer in the league with Arsenal last season.
"Robin made a massive impact in his first season," Van Nistelrooy told ManUtd.com ahead of the Red Heart United Legends match.
"Right from the beginning. He's been a great signing and it ended with him winning the league.
"He's a very good player in general. He scores the goals but, in nearly every goal that United score, he is a part of it with an assist or something else. He adds so much to the attacking play and will be very proud to win his first Premier League medal.
"I think he is definitely an example of a striker who can play the No. 9 and No. 10 roles together. He puts the goals in and provides a lot and I think, for a player of that quality, it's very rare. He is top class."
United are in a period of transition now following Sir Alex Ferguson's decision to retire and while Van Persie's place in incoming manager David Moyes' side appears guaranteed, the same cannot be said for his strike partner Wayne Rooney.
Rooney has endured a mixed season and also found himself shunted around the team into midfield positions.
"I like him playing further forward really," Van Nistelrooy said of Rooney.
"Where he can hurt people. I know he has shown that he can play in midfield as well. He has great vision of the the game and is a fine passer of the ball as well and, physically, can get about the pitch and get stuck in. He was doing that as well but I'd like to see him a bit more up front.
"I saw the game against Real at the Bernabeu and he was on the right but I'd prefer to see him in the centre rather than out wide. Danny Welbeck did really well that night - it was a big goal that he scored there and he had a good game."
Van Nistelrooy will appear in United's legends game against Real Madrid at Old Trafford on June 2.