Carroll, who moved from Tyneside to Liverpool for £35million in January 2011 and has since been loaned to West Ham, has enjoyed a return to form in recent weeks.
That comes in stark contrast to the Magpies, who remain embroiled in the scrap for Barclays Premier League survival after a 6-0 mauling by Carroll's parent club last weekend.
West Ham can inflict more pain on their former boss Alan Pardew if they win on Saturday afternoon and McDonald, an ex-Newcastle player himself, reckons Carroll will be up for the reunion.
"He is a forward and wants to score goals so I imagine he will be licking his lips after their performance against Liverpool last week," McDonald said.
"He is bound to find it strange because this is the club where he grew up and came through the ranks. That won't stop him trying to do his best for the team and he is fully committed to West Ham.
"He will be desperate to score and keep up his fine run of form."
Carroll has been tipped to return to Roy Hodgson's England squad for the end-of-season friendlies, and McDonald believes he would fit into the set-up with ease.
"When you're in form, you should be considered for England," he said. "I think the perception with his size is that he is just a big target man, but he is much more than that. He has excellent control, inter-link play and is of course fantastic in the air.
"He's not just a flick-it-up-and-hoof-it man - he would give England much more options than just a big ball up top. (Emile) Heskey did that sort of role for Michael Owen.
"People have that perception - he's more than a big lump and he does work at his game and is still a young man. He has gone to the top very quickly, but he is young and still learning."
McDonald also feels the 24-year-old is benefiting from playing away from the limelight of his home town.
"I think he is enjoying life in London and is not in the goldfish bowl of Newcastle or Liverpool and he is enjoying life and that is reflected in his performances," McDonald added.
"I think he is at a club where we care for him 100 per cent off the field as well as on it and we have settled him in to where he is living and he is comfortable where he is at."
Carroll did have a reputation for causing trouble off the field during his younger days and spent time living in the home of then Newcastle captain Kevin Nolan.
The two became firm friends and were reunited in east London when West Ham struck a deal to sign Carroll on a season-long loan.McDonald has enjoyed working with the forward and would welcome an extension to his stay at the club.
He said: "You might think he would be hard to work with, but he is a very unassuming young man who is working hard and trying to learn.
"He has done fantastically well considering he is in the spotlight all the time. It is a pleasure to work with him and, if things work out and he fancies staying and we can get him, he would be a great player to have."