Following events over the weekend, Monday is set to be a decisive day in the 2013/13 Premier League campaign.
After Manchester City's 3-1 loss at Tottenham, United can now claim an unassailable 16-point lead with a win over the Villans and claim a record 20th title.
Meanwhile, Villa, who are one place above the relegation zone, can condemn QPR and Reading to relegation if they manage to pull off an unlikely win at Old Trafford.
Ashley Young will miss the encounter against his former club after being ruled out for the remainder of the campaign with an ankle injury.
Paul Scholes (knee) is also out, although Sir Alex Ferguson reports no fresh injury concerns after last Wednesday's bruising encounter at West Ham.
Aston Villa manager Paul Lambert hopes to have in-form forward Gabriel Agbonlahor available.
The striker missed last week's draw with Fulham having suffered a groin injury in Villa's win at Stoke. However, he is back in training and should be in contention to feature at Old Trafford.
Young midfielder Gary Gardner is back in training after missing most of the season with knee ligament damage but is some way short of a return, while Chris Herd, Marc Albrighton (both foot) and Richard Dunne (groin) are still out.
Manchester United (from): De Gea, Lindegaard, Rafael, Smalling, Jones, Vidic, Ferdinand, Evans, Evra, Buttner, Nani, Valencia, Powell, Carrick, Anderson, Cleverley, Giggs, Kagawa, Van Persie, Rooney, Hernandez, Welbeck.
Aston Villa (from): Guzan, Given, Lowton, Vlaar, Clark, Lichaj, Stevens, Baker, Bennett, Sylla, El Ahmadi, Ireland, Westwood, Dawkins, N'Zogbia, Bannan, Holman, Benteke, Agbonlahor, Bent, Bowery, Weimann.