With leaders Manchester United not playing until Wednesday, City are well placed to pile on the pressure and Balotelli is expected to be in contention despite persistent rumours of an imminent move to AC Milan.
Assistant boss David Platt played down a deal this week, telling the media: "I don't think anything is going to happen. I can only go off what you know and I have seen. I know exactly the same as you, which is speculation."
QPR boss Harry Redknapp could bring back new striker Loic Remy after resting him for Saturday's FA Cup humiliation by third-tier MK Dons - and admits he must bring in new faces if his side are to stand any chance of avoiding the drop.
Redknapp, who twice failed in a bid for West Brom striker Peter Odemwingie this week, said: "I still think we can avoid relegation if we bring in the players that I'm aiming for. We will give ourselves a real chance."
In a crucial clash at Villa Park, Newcastle boss Alan Pardew is expected to hand Moussa Sissoko his Magpies debut, while fellow Frenchmen Mapou Yanga-Mbiwa and Yoan Gouffran are also in the squad.
Aston Villa, reeling from Friday's FA Cup defeat at Millwall, could be without ankle injury victim Fabian Delph, but boss Paul Lambert remains defiant, insisting: "Is the squad good enough to keep us up? Yes. Every game we go into I think we will win it."
Also on Tuesday, Sunderland are once again without Lee Cattermole as they face Swansea at the Stadium of Light, while Wigan boss Roberto Martinez will bring back his big names for the Latics' trip to Stoke.
Manchester United will get the chance to increase their lead at the top when they face Southampton at Old Trafford on Wednesday, hoping for more of their same after their 4-1 FA Cup stroll against Fulham.
Arsenal hope to pile on the misery for Brendan Rodgers' Liverpool at Anfield, with Rodgers set to react to his side's Sunday humiliation at Oldham by bringing back his big guns after warning his young players they blew their chance.
Rodgers said: "It is not enough to play for Liverpool and get up for Arsenal and Manchester City games, because if we are going to win trophies we need to be able to come to places like Oldham and win."
Everton hope to wrap up the signing of Dutch midfielder Leroy Fer in time for their Wednesday night clash with West Brom, who have spent most of the week resisting striker Odemwingie's bid to move on.
Tottenham are definitely without new boy Lewis Holtby for the trip to Carrow Road to face a Norwich side stunned by their FA Cup loss to non-league Luton.
Boss Chris Hughton said: "Every club will go through this. It's about how you bounce back."
Under-fire Chelsea boss Rafael Benitez will hope to bring back keeper Petr Cech for his side's trip to Reading, while Fulham new boy Emmanuel Frimpong could be available to face West Ham at Craven Cottage.
Tuesday's Premier League Fixtures
QPR vs Man City
Sunderland vs Swansea
Stoke vs Wigan
Aston Villa vs Newcastle
Wednesday's Premier League Fixtures
Arsenal vs Liverpool
Norwich vs Tottenham
Everton vs West Brom
Fulham vs West Ham
Reading vs Chelsea
Man United vs Southampton