The Blues played out a second successive goalless stalemate against west London rivals Fulham at Stamford Bridge on Wednesday night, which was a sixth Barclays Premier League game without a win.
The European champions have slipped off the pace at the top of the table and head to Upton Park for the early kick-off in third place, seven points behind Manchester United.
Blues midfielder Oriol Romeu said: "We have to keep going forward, look at the positive things and win the games and fight, fight, in each game."
West Ham went down 1-0 at Old Trafford to an early goal from Robin van Persie.
However, defender Guy Demel believes they can be positive ahead of the visit of the European champions.
"We don't need to hide because we have an opportunity to win the game," he said.
Arsenal manager Arsene Wenger has challenged his players to make the most of their home advantage against Swansea following a second successive draw at Everton.
He said: "If we play well at home and get the results at home we have a chance to come back."
Michael Laudrup's Swans are now up to eighth in the table, just a place behind the Gunners, and have lost just one of their last nine games in all competitions.
The Danish manager said: "Everyone will expect Arsenal to win, but we can go there with confidence."
Tottenham forward Clint Dempsey will return to Craven Cottage for the first time since he left Fulham in a £6million move.
The American said: "It came to a point for me where I didn't feel valued and appreciated, not by the fans, but by other situations."
Fulham come into the game on the back of their battling 0-0 draw at Chelsea.
Full-back John Arne Riise said: "We have got to take our momentum into the Tottenham game."
Liverpool host Southampton looking to bounce back from their midweek defeat at Spurs, which ended an eight-match unbeaten run.
Reds boss Brendan Rodgers said: "My job here is to gain results while developing a way and philosophy at the club."
Saints boss Nigel Adkins was a schoolboy at Anfield. He recalled: "I remember training with Ray Clemence, saving a penalty from Graeme Souness, you are alongside Alan Hansen and Kenny Dalglish in the small-sided games. As a kid you were just involved and joined in, which was great."
Manchester City hope James Milner, who scored in their midweek win at Wigan, be fit to face Everton.
"James scored a good goal and played very well. We are disappointed with his hamstring, but hope he recovers quickly", said Blues boss Roberto Mancini.
Leon Osman hopes the Toffees can recover their winning form after a draw with Arsenal was their sixth in eight games.
"We will try and find a solution in the next few days and will look to start picking up wins in the next few weeks," the midfielder said.
Harry Redknapp will take charge of his first home match as QPR boss when Aston Villa head to Loftus Road.
The Hoops battled to a goalless draw at Sunderland on Tuesday night.
Defender Ryan Nelsen said: "It is up to us now to bring in results for him, start producing on the field and getting some points."
West Brom manager Steve Clarke expects a response against Stoke after the high-flying Baggies were beaten 3-1 at Swansea.
"We had a chat about what we did wrong, and what we needed to do better and they did do better," he said.
Premier League leaders Manchester United travel to Reading in the late kick-off.
Midfielder Michael Carrick feels the Red Devils need to rediscover their mean streak following some disappointing defensive displays.
"We had a spell a few years ago when we really started games well and could have killed teams off, we want to try and get back to something near that," he said.
Royals boss Brian McDermott is aiming for an upset. He said: "We are playing at Madejski Stadium, and anyone that knows Reading knows that, in the last three years, how difficult a place it is for the opposition teams to come."
Norwich drew 1-1 at Southampton on Wednesday night, but will again be without injured England goalkeeper John Ruddy for Sunday's home match with Sunderland.
In Monday night's Premier League game, Newcastle and Wigan will look to recover from their midweek defeats.
Saturday's Premier League Fixtures
West Ham vs Chelsea
Romeu demands fight from Blues
Manchester City vs Everton
Mancini pleased with Milner impact
Arsenal vs Swansea
Reading vs Manchester United
Ferguson: Rafael proving his worth
QPR vs Aston Villa
Sunday's Premier League Fixture
Norwich vs Sunderland
Monday's Premier League Fixture
Newcastle vs Wigan