Chelsea vs Liverpool
Ashley Cole will again be missing for Chelsea, with a hamstring injury the cause of his absence. Captain John Terry will be pushing for a start in central defence after he was surprisingly left on the bench against Shakhtar Donetsk in midweek, while Frank Lampard is still out with a calf problem.
England full-back Glen Johnson is set to return for Liverpool against his former club after a hamstring injury. Goalkeeper Jose Reina is also making good progress in his recovery from a similar problem and may have a chance of being involved. Manager Brendan Rodgers is set to restore key players after resting most of his first-choice line-up for Thursday's Europa League clash against Anzhi Makhachkala.
Manchester City vs Tottenham
Manchester City trio Joleon Lescott, Maicon and David Silva are hoping to return to action against Tottenham. Defenders Lescott (back) and Maicon (foot) and playmaker Silva (hamstring) are all back in training after spells on the sidelines. Right-back Micah Richards (knee) and midfielders James Milner and Jack Rodwell (both hamstring) remain on the injury list.
Tottenham midfielder Sandro has a chance of recovering from a calf injury in time to play. Manager Andre Villas-Boas must decide whether to stick with Hugo Lloris or recall Brad Friedel in goal, and striker Emmanuel Adebayor could make his first league start of the season at his former club. Mousa Dembele (hip), Scott Parker (Achilles), Benoit Assou-Ekotto and Younes Kaboul (both knee) are unavailable.
Newcastle vs West Ham
Newcastle will be without two suspended senior men in midfielder Cheick Tiote and defender Fabricio Coloccini. Manager Alan Pardew, who made eight changes for the Europa League clash with Club Brugge in Belgium, is likely to restore most of his big names including Jonas Gutierrez, Hatem Ben Arfa and Demba Ba, but Danny Simpson (shoulder) remains a doubt and James Perch (thigh) is out for up to six weeks.
West Ham manager Sam Allardyce could face a defensive crisis. James Collins and James Tomkins will have fitness tests on Saturday to determine whether they are available to play, otherwise Allardyce will be left with only one fit central defender in Winston Reid. Full-back Guy Demel has returned to training following a hernia problem but Matthew Taylor (calf), Ricardo Vaz Te (shoulder) and Jack Collison (knee) remain sidelined.