United are the only one of the top three in action on Saturday when they travel to Villa Park, with nearest rivals Chelsea and champions Manchester City facing home games with Liverpool and Tottenham respectively on Sunday.
Sir Alex Ferguson's side secured top spot in their Champions League group and a place in the knockout stages with a 3-1 win at Braga on Wednesday.
And Wayne Rooney wants the Red Devils to continue such success for the rest of November in the trips to Villa, Norwich and Galatasaray before ending the month against QPR and West Ham at Old Trafford.
"We're in a good position and we know we can play better football," Rooney said. "Now we have a run of games where we feel we can get maximum points, so hopefully we can do that."
Chelsea and Manchester City return to league action in contrasting moods following the latest round of Champions League fixtures, with European champions Chelsea claiming a last-gasp win over Shakhtar Donetsk and City denied a last-second penalty in a 2-2 home draw with Ajax.
Victor Moses scored Chelsea's winner and the 21-year-old believes he has plenty more to offer at Stamford Bridge following his £9million summer move from Wigan.
He said: "With the quality of players we've got, I learn from them as well and that's the only way you can improve, playing around good players such as this. There is still a lot more to come from me."
At the other end of the table, bottom side Southampton are at home to Swansea in a game the Saints might need to win to save manager Nigel Adkins' job.
Despite being under pressure after seeing his side concede 28 goals and suffer eight defeats in their opening 10 games, Adkins is relishing the challenge.
"I love being the manager of Southampton," he said. "I don't like being bottom of the division but I love the situation we're in. You find out about yourself, you find out about other people and I want to be in the Barclays Premier League.
"I want to be a manager for a long period of time. We worked very hard to get into this situation."
Arsenal and Fulham are separated by just goal difference as they meet at the Emirate Stadium, while Everton will be out to cement their place in the top four with victory at home to struggling Sunderland.
Reading take on Norwich at the Madejski Stadium still looking for their first win of the season, while Wigan are at home to high-flying West Brom.
Sunday's other game sees Newcastle at home to West Ham.
Saturday's Premier League Fixtures
Stoke vs QPR
Reading vs Norwich
Wigan vs West Brom
Martinez hails Clarke success with Baggies
Southampton vs Swansea
Arsenal vs Fulham
Everton vs Sunderland
Aston Villa vs Man United
Sunday's Premier League Fixtures
Man City vs Tottenham
Newcastle vs West Ham
Chelsea vs Liverpool