The Red Devils will leapfrog Chelsea - even if only temporarily - if they beat the Gunners and Ryan Giggs believes United's youngsters will benefit from Wednesday night's 5-4 loss to Chelsea in the Capital One Cup, telling MUTV: "It's tough to take. When you score four goals away from home more often than not you win the game.
"But they'll learn from it and the experience they'll gain from this is more than they could ever get from a reserve game."
Manager Arsene Wenger hopes Arsenal will not have to cash in on contract rebel Theo Walcott during the January transfer window.
Walcott's current deal expires next summer, with his representatives and the club still some distance apart over wages and Walcott also expressing concerns over opportunities in his preferred central role.
Asked by Press Association Sport if Arsenal would have to sell Walcott were no new deal signed by the start of 2013, Wenger said: "I would not like to. I have not even thought about that, because at the moment I think we will still manage to make a deal with him."
Gary Cahill has insisted Chelsea's trophy charge would not be derailed by the Mark Clattenburg affair after helping them stay in the Capital One Cup by the skin of their teeth.
Victory came on the back of the club's allegations that referee Clattenburg used "inappropriate language" towards John Obi Mikel - something Clattenburg is understood to strenuously deny, little more than a year after the start of the John Terry racism row.
On top of those allegations, the Metropolitan Police on Thursday confirmed it had opened an investigation into alleged racist behaviour by a Chelsea supporter.
A photograph published in the national press appeared to show a fan making a 'monkey' gesture on Wednesday night with the club also launching their own investigation into the incident.
Speaking ahead of the Barclays Premier League trip to Swansea on Saturday, Cahill said: "It's important that we don't let anything affect us and we showed that won't happen.
"Whatever is going on off the pitch, players relish playing football."
Swansea will be a tricky match for the Blues with the Swans sitting in mid-table having made a decent start to the season.
Pablo Zabaleta has eased Manchester City manager Roberto Mancini's defensive injury concerns by declaring himself fit for the trip to West Ham.
The champions feared having no fit specialist right-back after Micah Richards last week joined Zabaleta and Maicon on the injury list.
But Zabaleta, after sitting out three matches with a hamstring injury suffered on international duty, is now ready to return.
The 27-year-old told the club's website: "I feel good, I've been training with the team and I think I should be fine to play on Saturday."
Fourth-placed Tottenham host Wigan, Everton, in fifth, visit Fulham with both teams hoping to take advantage of any slip-up by Spurs.
Norwich seek their second home win of the season against Stoke while fourth-bottom Aston Villa visit Sunderland, who have only one league win this season.
Two teams who look destined to struggle all season meet when bottom side QPR host third bottom Reading on Sunday.
Liverpool will look to add to their two league victories when they host Newcastle who have yet to win away this season.
Monday night's game pits West Brom, who have impressed this season, against second-bottom Southampton.
Saturday's Premier League Fixtures
Manchester United vs Arsenal
Fulham vs Everton
Sunderland vs Aston Villa
Swansea vs Chelsea
Tottenham vs Wigan
Norwich vs Stoke
West Ham vs Manchester City
Sunday's Premier League Fixtures
QPR vs Reading
Liverpool vs Newcastle
Monday's Premier League Fixtures
West Brom vs Southampton