The likes of Ashley Williams, Leon Britton, Jonathan de Guzman and Danny Graham were all struggling with various ailments before the weekend defeat to Everton and are likely to be rested.
Chico Flores serves the last game of a three-match suspension while Nathan Dyer misses out after his red card against the Toffees.
Record signing Pablo Hernandez is a doubt with a knee injury while Itay Shechter will not feature as he observes the Jewish holy day of Yom Kippur.
Claude Davis could return to the Crawley starting line-up.
The Jamaican defender had missed the last four matches with a hip injury but was on the bench against Tranmere at the weekend.
And boss Richie Barker will be considering throwing Davis back in after watching his side crash 5-2 at home to the League One leaders.
Winger Sergio Torres is also available having missed five games with a leg injury, so midfielder Shaun Cooper is the only casualty due to a groin problem.
On-loan strikers Jonathan Forte and Nicky Ajose are eligible to play in the competition and could both start up front if Barker opts to rest skipper Gary Alexander.