The west London derby will be the first meeting between the two clubs since Blues captain John Terry was cleared in court of using a racial slur against the Hoops' Anton Ferdinand in the corresponding fixture last October.
Terry, who remains the subject of a Football Association investigation over the incident and denies their charge against him, had been a doubt for the clash but is reportedly winning his battle with an ankle injury sustained on England duty.
Ferdinand is also recovering well after a shoulder injury, meaning the defenders are on course to play against each other for the first time since Terry's trial in July.
The match could also involve Chelsea left-back Ashley Cole, another recovering from injury, following his appearance as a character witness for Terry.
Consequently, there has been speculation as to whether or not Ferdinand would shake some of his counterparts' hands before kick-off - a tradition that was abandoned in advance of two other encounters between the clubs last season following the October match - and Press Association Sport understands QPR are liaising with Chelsea on how to approach the matter.
While second-bottom QPR have only a point to show from their three Premier League games this term, Chelsea - the only side to have won all of their top-flight matches so far - are top of the table on nine points, two better off than champions Manchester City, who face a tricky-looking trip to Stoke.
The Britannia Stadium has become something of a bogey ground for City, beaten twice and held to three draws there in their last five visits in all competitions.
There is an element of the unknown about Saturday's encounter, though, given the number of debutants that could be on display.
The contest brings together two of the most busy clubs from the end of the transfer window and among those who could make their first appearances for their new team is former England striker Michael Owen for the Potters and Brazilian full-back Maicon for City.
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Manchester United, a point behind City, host Wigan and if fit to play, Red Devils frontman Robin van Persie will be hoping to continue his explosive goalscoring start for the club.
Van Persie's hat-trick against Southampton on September 2 meant he had netted four times in two starts for United, although he came off injured on Tuesday night during Holland's World Cup qualifier against Hungary and will have his condition assessed ahead of the Latics match.
Saturday's other 3pm kick-offs see Van Persie's former employers Arsenal - still to concede a goal this season - at the Emirates Stadium to take on a Southampton side who are yet to register a point, struggling Aston Villa entertain high-flying Swansea and another team who have started well, West Brom, play at Fulham.
The early kick-off that day pits Norwich against West Ham at Carrow Road, while Liverpool, keen to get their league campaign going after a draw and two defeats, will play Sunderland.
On Sunday, Andre Villas-Boas takes his search for his first win as Tottenham manager to Reading - who like QPR, Villa and Liverpool, have just one point to their name - and on Monday, Everton and Newcastle meet at Goodison Park.
Saturday's Premier League Fixtures
Norwich vs West Ham
Stoke vs Man City
QPR vs Chelsea
Man United vs Wigan
Fulham vs West Brom
Aston Villa vs Swansea
Arsenal vs Southampton
Sunderland vs Liverpool
Sunday's Premier League Fixtures
Reading vs Tottenham
Monday's Premier League Fixtures
Everton vs Newcastle