Brendan Rodgers' men bounced back from a humiliating defeat at West Brom on the opening day with a fine performance against Manchester City last weekend, but two defensive mistakes meant Liverpool had to settle for a point.
Nuri Sahin could make his Anfield bow with Brazilian midfielder Lucas set to be ruled out for up to three months with a thigh injury, while teenager Raheem Sterling could retain his place after impressing on his league debut against Roberto Mancini's side.
With Sahin ineligible for the Europa League play-off against Hearts, Rodgers told liverpoolfc.tv: "We'll assess the player over the next few days and I'm sure he'll be involved in the squad at the weekend."
Arsenal will be making the trip to Merseyside looking to score their first goals of the season after failing to find the net since Robin van Persie's departure to Manchester United.
Two goalless draws indicate defence has not been a problem, but they could nonetheless be strengthened in that area as manager Arsene Wenger revealed: "(Laurent) Koscielny will be back in the squad. (Wojciech) Szczesny has a test tomorrow [Friday] and Saturday."
He added: "We have not conceded but we played against two teams who restricted us to few chances. That is why Liverpool is a good test, because it is a team who will defend well and attack well."
In Saturday's late kick-off, champions Manchester City host QPR in a repeat of last season's epic final-day fixture.
Roberto Mancini was happy to take a point at Liverpool last weekend thanks to Carlos Tevez's late strike, but he will be expecting his side to return to winning ways this time.
City will again be without Sergio Aguero, the man who scored the last-gasp winner against Mark Hughes' side last season, through injury.
QPR head to Eastlands with fond memories having maintained their Barclays Premier League status there in May, despite defeat on the final day. They could have a number of new players at their disposal ahead of the clash, with Brazilian goalkeeper Julio Cesar likely to make his debut.
Rangers responded to their 5-0 thrashing by Swansea on the opening day with a point at Norwich last weekend and their confidence will have been boosted by a comprehensive Capital One Cup victory over Walsall in midweek.
Manchester United travel to St Mary's to take on promoted Southampton after picking up their first win of the season against Fulham last weekend but will be without Wayne Rooney, who is set to miss up to a month through injury.
The Saints are still looking for their first win of the campaign after they followed a creditable display at Eastlands on the opening weekend with a poor home defeat to Wigan last time around.
Swansea and Everton will be hoping to continue their 100% starts to the new season, as Michael Laudrup's side host Sunderland while the Toffees travel to West Brom.
Elsewhere, Tottenham welcome Norwich to White Hart Lane with both sides still searching for their first win.
Fulham make the trip across London to face Sam Allardyce's West Ham, looking to bounce back from their narrow defeat at Old Trafford, while Wigan and Stoke meet at the DW Stadium.
On Sunday, Alan Pardew's Newcastle entertain an Aston Villa side still to register a point.
Saturday's Barclays Premier League Fixtures
West Ham vs Fulham
West Brom vs Everton
Swansea vs Sunderland
Tottenham vs Norwich
Wigan vs Stoke
Man City vs QPR
Sunday's Barclays Premier League Fixtures
Liverpool vs Arsenal
Newcastle vs Aston Villa
Southampton vs Man United