United went down 1-0 in the Barclays Premier League clash at Goodison Park on Monday night thanks to Marouane Fellaini's second-half header.
It was the first time in eight years that the Red Devils had lost their opening league fixture of the season and they now face a Fulham side who made a superb start to their own campaign last weekend by thrashing Norwich 5-0.
Ferguson is mindful of the White's threat, but is demanding nothing less than a positive reaction from his team tomorrow - and is confident they will deliver.
"I went to see Fulham last Saturday and they played very well," Ferguson said.
"It's a football club that's grown tremendously since Roy (Hodgson) got them to the Europa League final (in 2010).
"The place is buzzing with a full-house every week and there's a good atmosphere around the place.
"They have a lot of experience in their team. It won't be an easy game, but we're at home and we need to make an impact quickly after losing on Monday night, and we expect that."
Robin van Persie came off the bench to make his United debut in the Everton match and the Holland striker - signed for a reported £24million last week from Arsenal - looks set to be promoted to the first XI, with Ferguson today saying there was "every chance" he could start against Fulham.
The manager also confirmed Van Persie's Dutch compatriot and fellow new recruit, full-back Alexander Buttner, will be involved, most likely starting on the bench, and that he will once again be without the defensive quartet of Phil Jones (back), Jonny Evans, Chris Smalling (both foot) and Rio Ferdinand (leg) that was unavailable for the Goodison Park contest, although Jones has now returned to training.
Buttner, whose move to United from Vitesse Arnhem was confirmed on Tuesday, is the fourth new arrival of the summer at Old Trafford following the signings of Van Persie and midfielders Nick Powell and Shinji Kagawa, while United also announced this week that striker Angelo Henriquez is to join them from Universidad de Chile having been granted a work permit.
Speaking at a press conference this morning to preview the Fulham game and where Buttner was being officially unveiled, Ferguson said the Red Devils will not be buying any more players in the current transfer window after a deal for Chilean 18-year-old Henriquez is tied up in the next few days.
``We definitely won't be buying anyone else, that is for sure,'' Ferguson said.
The likes of striker Dimitar Berbatov and winger Nani have been linked with moves away from Old Trafford and asked if there would be any likely departures, Ferguson said: ``There is no movement I can tell you about, to be honest with you.
``There is only a few days left now until the deadline and that will pass quite quickly I would imagine.''
Ferguson's latest acquisition Buttner has been brought in as back-up to left-back Patrice Evra.
"We've been monitoring Alexander for a while," Ferguson added. "He's a straightforward attacking, quick full-back who will be a terrific addition to our squad.
"Patrice is in his 30s now, although he is still a fit lad. Alex gives us a good back-up and a good challenge for that position."
Buttner, 23, said: "I feel good. It's a dream for me to play for a big club like Manchester United. I can't wait to play for the team and let people see what I can do.
"I know I have to wait for my chance. I can learn so much from Patrice and I cannot wait to play with him. It's a nice club and everyone has helped me settle in."
Referring to Henriquez, Ferguson said: "We've had an option (on him) since he was 14 when he played against our youth team.
"He came over when he was 15 and then 16 so we had close contact with him in that respect. When he got to 18 it was a matter of should we leave him for another year or bring him in?
"He had such a good summer with Chile's under-20s that we thought it wasn't worth waiting, we may as well do it now.
"He's quick and a good finisher and he has a terrific physique for a boy of 18. He should be here on Sunday."