The Potters are safe in mid-table but will have a potentially decisive say in who goes down as they prepare to face Rangers on Sunday and Bolton next weekend.
Those two teams and Blackburn appear in the most danger of joining Wolves in the npower Championship next season, but Wigan and Aston Villa are not safe yet.
Stoke could be forgiven for winding down at the end of a season that started in July, but they still have targets of their own to strive for, with a top-10 finish not yet out of reach.
Pulis said of Sunday's clash: "It's going to be a big game. It's important we approach it in the right manner. We want to get as many points as we possibly can.
"Obviously it's very important for QPR and the teams at the bottom of the table and I understand we have a responsibility, but as a football club we want to do well ourselves. We have a responsibility to ourselves first and foremost, never mind anybody else.
"I know all the emphasis will be on QPR and Bolton but, as a football club we have to have the respect, dedication and determination to go on and do as well as we can.
"We've still got a chance of getting 50 points so we'll work our socks off to do that. It'll be like a cup final for them, it has to be, and we have to be ready for it."
QPR go into the match outside the bottom three on goal difference but, with a trip to Manchester City to come on the final day of the season, anything but victory would leave them looking very vulnerable.
No team has a starker contrast between their home and away form of late, with last weekend's 6-1 hammering at Chelsea their sixth away defeat in succession, while their last four home games have brought wins over Liverpool, Arsenal, Swansea and Tottenham.
Pulis admitted he is surprised Rangers are in the relegation scrap, and he added: "We're absolutely delighted not to be in that position. It's a tough position to be in, now it's a two-game season for some of them.
"It'll be tough down at Loftus Road with a full house. They know everything is determined by their next two performances, and so do Bolton.
"QPR have got good players. If you look at their squad they're most probably disappointed to be where they are. But they are where they are and they have to get out of it.
"Their home form has kept them in the league so far. If you look at their last four home results, they're phenomenal results against four top teams."
Sunday's match will be Stoke's 55th of the season and third in eight days but, aside from confirming Thomas Sorensen will play in goal as part of his European Championship preparations, Pulis has no firm plans to shuffle his squad.
He said: "I'll see how the players are. Everybody in the squad still wants to play and that's why they're here. If we leave people out, they're disappointed."