Although Wanderers have been beaten five times at White Hart Lane in all competitions since Coyle was appointed as their manager in January 2010, at home they have held Spurs to a 1-1 draw in the FA Cup and pulled off an impressive 4-2 league win over them.
The Scot was previously in charge at Burnley, who in 2009 - aiming to overturn a 4-1 deficit from the first leg - went 3-0 up against Tottenham at Turf Moor to take their Carling Cup semi-final to extra-time, before goals from Roman Pavlyuchenko and Jermain Defoe saw the visitors progress 6-4 on aggregate.
Those experiences have given Coyle plenty of encouragement that Bolton can put fourth-placed Spurs to the sword on Wednesday as the Trotters look to climb out of the relegation zone.
"I think Spurs are a different proposition away from home than they are at White Hart Lane," Coyle said.
"I have had two encounters with Spurs at the Reebok Stadium - a fifth-round FA Cup tie which we drew and should have won, and then when we beat them last season in the Premier League.
"So we go into this believing that if we are at our best, we can take points from the game, and that is what we will look to do.
"Also, there was the Carling Cup semi-final with Burnley when we beat them 3-0 over 90 minutes on the night.
"Tottenham at White Hart Lane are absolutely formidable, but at the Reebok we believe we have a real opportunity to win the game."
Bolton are currently 18th in the table, separated from 17th-placed QPR by goal difference alone.
Wanderers have three matches left, with this one being their game in hand over the rest of their relegation rivals.
They had another last week, triumphing 2-1 at Aston Villa, and Coyle - whose team then went on to draw 2-2 at Sunderland on Saturday, taking their haul to 14 points from the last 24 on offer - wants to see his men make the most of their opportunity once again.
"What we have to do now is, as we did last week against Aston Villa, capitalise on our game in hand," Coyle said.
"We have had to sit for a few weeks and play catch-up in terms of games, while opponents picked up some huge results that were probably not expected.
"But now they would have to say Bolton are on a terrific run of form.
"We have won a tough away game (at Villa), picked up a point at Sunderland where we could have won and now we have three games left, knowing that we need to take the points to make sure we have at least one more than three teams below us.
"We know we are capable of doing that."