De Vries will make only his second league appearance since his move from the Liberty Stadium against Brendan Rodgers' side in place of the injured Wayne Hennessey.
But the Dutchman is philosophical about how events have mapped out during the past nine months and is looking to establish himself as number one while Hennessey recovers from knee ligament surgery.
De Vries said: "I had some great years at the Liberty Stadium, great memories. Swansea deserve to be where they are at the moment, they've had a great season.
"A lot of the players have been there since League Two and to show their quality at Premier League level, and the way they play, is magnificent.
"I had a great connection with the supporters although it might be a little bit different on the weekend!"
With regard to his move to Molineux, De Vries said: "It's easy to look later on. I don't have a magic wand and no one can predict the future.
"I always thought Swansea, with their style, would be suited to playing at Premier League level but looking back, at the time I signed for Wolves, I had a good feeling for Wolves.
"There are no 'ifs' because I cannot turn back time and, at the time it felt the right choice. I'm sticking with that."
De Vries has no doubts that Rodgers will manage one of the top Premier League clubs in the future.
He said: "It doesn't surprise me at all that Brendan is being tipped for bigger things in his career.
"Tactically, he is really up there, his training methods are really good. He is still a young manager but I see him doing bigger things. I regard him really highly.
"I wouldn't be surprised if eventually he ends up at one of the big clubs. I know his character, he is obsessed by the game, has a great vision, and I've got nothing but positive things to say about him."
De Vries is challenging Wolves to end the season on a high despite going down ahead of plotting for an instant return to the top flight.
He said: "Although we got relegated, we want to make a positive ending in the last three games for us.
"We owe it to the fans for whom it has been a horrible season as well as for everyone involved with the club.
"In the last three games we want to create a positive feeling going into the summer break, reflect on the season, and then kick on next season.
"From the start you've got to be ready for the Championship."
Wolves will be without on-loan Tottenham defender Sebastien Bassong at the Liberty Stadium.
Bassong suffered a hamstring injury during Sunday's 2-0 home reversal by Manchester City and will be sidelined for up to a fortnight.
Christophe Berra is poised to replace Bassong as interim manager Terry Connor searches for his first win at the 11th attempt.