After taking on all comers in the first half of the season, Spurs have gone winless in their last four games after losing 5-2 to Arsenal in the north-London derby, and have slipped behind the Gunners in fourth.
And with just five points separating them and fifth-placed Chelsea, a loss would severely jeopardise Spurs' chances of finishing in the top four come the end of the season.
Manchester City could be back on top of the Barclays Premier League on Saturday when they travel to Stoke, with current leaders Manchester United only in action on Monday when they entertain Fulham.
The Citizens will be buoyed by Wednesday's come-from-behind victory over Chelsea, and it will be interesting to see what kind of role Carlos Tevez plays, after the Argentinean came off the bench to set up Samir Nasri's winner.
In-form Arsenal will be looking to strenghten their grip on third place when they host Aston Villa, while Liverpool are seeking to bounce back from Wednesday's shock 3-2 loss to QPR when they welcome Wigan to Anfield.
Relegation-threatened Wolves will be desperate to pick up points when they travel to Carrow Road to play Norwich, while Blackburn will be looking to move further away from the relegation zone when they visit 18th-placed Bolton, who will undoubtedly still be reeling from Fabrice Muamba's collapse in last weekend's FA Cup tie against Tottenham.
Elsewhere on Saturday, Swansea entertain Everton while QPR travel to play Sunderland.
Sunday's only match sees West Brom take on Newcastle.
Saturday's Premier League Fixtures
Chelsea vs Tottenham
Norwich vs Wolves
Bolton vs Blackburn
Arsenal vs Aston Villa
Swansea vs Everton
Liverpool vs Wigan
Sunderland vs QPR
Stoke vs Man City
Sunday's Premier League Fixtures
West Brom vs Newcastle
Monday's Premier League Fixture
Man United vs Fulham