Torres has given Di Matteo a selection headache for the Barclays Premier League game at Manchester City after finally breaking his long goalscoring drought in Sunday's FA Cup thrashing of Leicester.
Drogba is still expected to get the nod at the Etihad Stadium but caretaker manager Di Matteo has not ruled out pairing Torres with the Ivorian in future.
The duo failed to perform in tandem under Carlo Ancelotti last season, while Andre Villas-Boas did not even try to do so, always preferring to start with a lone striker.
But Di Matteo was adamant Drogba and Torres could play together.
Asked if he would change the system to accommodate both, he said: "If the game requires it, yes.
"We tried it in the Napoli game."
Di Matteo, whose four games in charge have seen him use a 4-2-3-1 formation, welcomed the selection dilemma.
"It's great for this football club, isn't it?" he said.
"To have that firepower in the team, it's fantastic. And we will try to do our best to try to exploit the good form of both.
"It's going to be tough on anybody I leave out.
"We have a fantastic squad and it hurts to leave players out of that calibre. It's really difficult.
"I can only field 11 positions and the ones on the bench."
Daniel Sturridge also covets the centre-forward role at Chelsea and appeared reluctant to pass to Torres from his position out on the wing on Sunday.
Di Matteo said: "I wouldn't think it's difficult to play for the team.
"Every player has to put his individual qualities within the team for the benefit of the team."
He added: "We forget that he's a very young player, a very young man, and really this is his first full season with his club.
"He's still developing if you think about it for his age and how many game's he's played.
"There is certainly some incredible talent that you can improve and he can make the team help and win more games.
"I think he could play down the centre.
"He has the ability to play in both positions."
Meanwhile, Di Matteo was confident captain John Terry would be fit for the rest of Chelsea's nightmare schedule of matches after ruling him out of the game.
Terry has been struggling with a calf strain since his second outing after his remarkable comeback from knee surgery.
Di Matteo said: "He did very well to come back from his operation and he's then played two games in a very short period of time, very intense games as well.
"He's fine for Saturday."